The more public speaking engagements you do, the more you’ll realize that every industry has its own set of acronyms. Ophthalmologists see PRD as the definition for Progressive Retinal Degeneration while scientists may receive that to mean Proton Recoil Detection. Use acronyms and abbreviations to create a tailored joke for your audience. You can do this by changing one or more of the words to something still relative to the industry you are focusing on.
For example, I was giving a public speaking presentation to hotel industry representatives. At the time, President Clinton had proposed taxes that would affect their industry. Creative thinking and a little knowledge of the industry enabled me to change the acronym, OCC, which usually means Occupancy Rate, to Oh! C’mon Clinton! This definitely had the public speaking audience ROTFL (rolling on the floor laughing)!